Joel C. Bornstein

Nov 1, 2024 | jci.org | Joel C. Bornstein |Hana Janova |Thaddeus S. Stappenbeck |Michael Diamond

AbstractLoss of enteric neurons leading to long-term gastrointestinal dysfunction is common to many diseases, and the path to functional recovery is unclear. In this issue of the JCI, Janova et al. report that West Nile virus killed enteric neurons and glia via CD4+ and CD8+ T cells acting through the perforin and Fas ligand pathways. Enteric glial cells contributed to neurogenesis and at least partial replacement of affected neurons.

Aug 10, 2023 | frontiersin.org | Pietro Enea |Joel C. Bornstein

Over the last decade, there has been growing interest and important developments in Autonomic Neuroscience research. In this Research Topic, an international selection of high-quality papers highlighted the latest advancements and the improvements in the research techniques, offering new insights into the role of autonomic nervous system (ANS) activity in regulating metabolic pathways and multiple systems such as cardiovascular, gastrointestinal, renal and immune system.

Jul 21, 2023 | frontiersin.org | Joel C. Bornstein |Wolfgang Reindl |Shihao Duan |Guo Xiang-jie

1. IntroductionInflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the gastrointestinal tract characterized by episodes of relapse and remission. A growing number of studies have suggested that IBD is highly associated with psychiatric disorders like anxiety and depression (1–5).

May 1, 2023 | frontiersin.org | Biomedical Engineering |Joel C. Bornstein

1. IntroductionThe functional anatomy of somatic peripheral nerves has been well-studied with serial histological tracing. It has been shown that fascicles observed on a nerve cross-section map logically to supplied dermatomes and muscle groups (Bäumer et al., 2015; Shearer, 2019). The human vagus nerve is the main peripheral nerve of the autonomic nervous system (ANS) and provides innervation to about eight visceral organs in the thorax and abdomen as well as the larynx.

Feb 28, 2023 | frontiersin.org | Joel C. Bornstein |Junichiro Hayano |Andreas Voss

1. Introduction The heart and brain connect via both electrical and hemodynamic interactions (Figure 1).