Joel D. Quispe

Nov 20, 2023 | cell.com | Samantha Zepeda |Ashley Taylor |Joel D. Quispe |Byarugaba D.K

Highlights • PRD-0038 clade 3 sarbecovirus spike has a broad ACE2 receptor usage • RBD mutations expand tropism to additional Rhinolophus ACE2s and to human ACE2 • Cryo-EM blueprints explain receptor tropism and spike antigenicity • Identification of PRD-0038 cross-neutralizing antibodies for pandemic preparedness Summary Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins...