Samantha Zepeda

Nov 20, 2023 | cell.com | Samantha Zepeda |Ashley Taylor |Joel D. Quispe |Byarugaba D.K

Highlights • PRD-0038 clade 3 sarbecovirus spike has a broad ACE2 receptor usage • RBD mutations expand tropism to additional Rhinolophus ACE2s and to human ACE2 • Cryo-EM blueprints explain receptor tropism and spike antigenicity • Identification of PRD-0038 cross-neutralizing antibodies for pandemic preparedness Summary Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins...

Sep 18, 2023 | dialnet.unirioja.es | Gabriela Hernandez |Samantha Zepeda |Itzel Morales Juarez |Godina Hernández

Godina Hernández, Gabriela[1];Zepeda, Samantha[2];Morales Juarez, Itzel[1][1]Hospital Infantil De Morelia Eva Samano De Lopez Mateos: Morelia Michoacán, México. [2]Department of Biochemistry, University of Washington, USALocalización: Revista de Odontopediatría Latinoamericana, ISSN 2174-0798, Vol. 13, Nº. 0, 2023Idioma: españolTítulos paralelos: Manejo estomatológico minimamente invasivo em paciente pediátrico com tetralogia de Fallot: Relato de um caso.

Sep 13, 2023 | biorxiv.org | Jimin Lee |Samantha Zepeda |Young-Jun Park |Ashley Taylor

AbstractAlthough Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized. Here, we show that the African Rinolophus bat clade 3 sarbecovirus PRD-0038 S has a broad ACE2 usage and that RBD mutations further expand receptor promiscuity and enable human ACE2 utilization. We determined a cryoEM structure of the PRD-0038 RBD bound to R.

Mar 1, 2023 | nature.com | Samantha Zepeda |Guangfeng Zhou |David Veesler |Andrew Muenks

Creating the protein-ligand datasetAll single-particle EMDB entries with an associated ligand bound structure at 6 Å nominal resolution or better as of September 03, 2021 were obtained. Given the specificity of trying to model ions and glycans, structures with only these types of ligands were excluded from the dataset. In addition, the set had several cases with small molecules in close proximity.