Samantha Zepeda

Nov 20, 2023 | cell.com | Samantha Zepeda |Ashley Taylor |Joel D. Quispe |Byarugaba D.K

Highlights • PRD-0038 clade 3 sarbecovirus spike has a broad ACE2 receptor usage • RBD mutations expand tropism to additional Rhinolophus ACE2s and to human ACE2 • Cryo-EM blueprints explain receptor tropism and spike antigenicity • Identification of PRD-0038 cross-neutralizing antibodies for pandemic preparedness Summary Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins...

Sep 18, 2023 | dialnet.unirioja.es | Gabriela Hernandez |Samantha Zepeda |Itzel Morales Juarez |Godina Hernández

Godina Hernández, Gabriela[1];Zepeda, Samantha[2];Morales Juarez, Itzel[1][1]Hospital Infantil De Morelia Eva Samano De Lopez Mateos: Morelia Michoacán, México. [2]Department of Biochemistry, University of Washington, USALocalización: Revista de Odontopediatría Latinoamericana, ISSN 2174-0798, Vol. 13, Nº. 0, 2023Idioma: españolTítulos paralelos: Manejo estomatológico minimamente invasivo em paciente pediátrico com tetralogia de Fallot: Relato de um caso.

Sep 13, 2023 | biorxiv.org | Jimin Lee |Samantha Zepeda |Young-Jun Park |Ashley Taylor

AbstractAlthough Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized. Here, we show that the African Rinolophus bat clade 3 sarbecovirus PRD-0038 S has a broad ACE2 usage and that RBD mutations further expand receptor promiscuity and enable human ACE2 utilization. We determined a cryoEM structure of the PRD-0038 RBD bound to R.