Jofre Seira Curto

Jan 24, 2025 | biorxiv.org | Jofre Seira Curto |Sandra Hernandez |Sandra Hernández

AbstractProtein aggregation is a complex process influenced by environmental conditions and interactions between multiple molecules, including those of exogenous origin. Although in vitro simulations of aggregation are crucial for advancing research, few studies explore cross-seeding as a repeating event, despite the potential for such events when proteins circulate through the body.

Oct 20, 2023 | biorxiv.org | Jofre Seira Curto |Adan Martínez |Martina Garcia |Paula Sotillo Sotillo

AbstractOur life is intricately connected to microorganisms through infection or symbiotic relationships. While the inter-species propagation of prion-like proteins is well-established, their presence in the microbiome and impact on the host remains largely unexplored. To address this, we conducted a systematic study integrating in silico, in vitro, and in vivo analyses, showing that 63% of the gastrointestinal tract microbiome encodes prion-like sequences.