Paula Sotillo Sotillo

Oct 20, 2023 | biorxiv.org | Jofre Seira Curto |Adan Martínez |Martina Garcia |Paula Sotillo Sotillo

AbstractOur life is intricately connected to microorganisms through infection or symbiotic relationships. While the inter-species propagation of prion-like proteins is well-established, their presence in the microbiome and impact on the host remains largely unexplored. To address this, we conducted a systematic study integrating in silico, in vitro, and in vivo analyses, showing that 63% of the gastrointestinal tract microbiome encodes prion-like sequences.