Johan Vande Voorde

2 months ago | nature.com | Arafath K. Najumudeen |Johan Vande Voorde

Accurately measuring metabolites is crucial to understand the complex biochemical processes within tissues and organisms. Traditionally, this measurement is achieved by mechanical or chemical disruption of cells to release metabolites into an extraction solution. Careful formulation of this solution enables enrichment of specific classes of molecules while reducing the abundance of others.

Aug 14, 2023 | nature.com | Johan Vande Voorde |Rory T. Steven |Arafath K. Najumudeen |Chelsea J. Nikula |Yuchen Xiang |Lauren Ford | +22 more

AbstractThe genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models, and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine.

Mar 12, 2023 | biorxiv.org | Johan Vande Voorde |Arafath K. Najumudeen |Rory T. Steven |Chelsea J. Nikula

New Results doi: https://doi.org/10.1101/2023.03.12.531945 AbstractWith colorectal cancer (CRC) being the second most common cause of cancer-related deaths worldwide, there is an urgent need for better diagnostic tools and new, more targeted therapies. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine.