Arafath K. Najumudeen

2 months ago | nature.com | Arafath K. Najumudeen |Johan Vande Voorde

Accurately measuring metabolites is crucial to understand the complex biochemical processes within tissues and organisms. Traditionally, this measurement is achieved by mechanical or chemical disruption of cells to release metabolites into an extraction solution. Careful formulation of this solution enables enrichment of specific classes of molecules while reducing the abundance of others.

Nov 13, 2024 | nature.com | Christos Kiourtis |Maria Terradas-Terradas |Stephanie May |Anastasia Georgakopoulou |Amy Collins |Eoin D O’Sullivan | +14 more

AbstractCellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood.

Aug 29, 2023 | biorxiv.org | Sigrid K Fey |Arafath K. Najumudeen |Catriona A. Ford |Kathryn L. Gilroy

AbstractPancreatic cancer is characterised by the prevalence of oncogenic mutations in KRAS. Previous studies have reported that altered Kras gene dosage drives progression and metastatic incidence in pancreatic cancer. While the role of oncogenic KRAS mutation is well characterised, the relevance of the partnering wild-type KRAS allele in pancreatic cancer is less well understood and controversial.

Aug 14, 2023 | nature.com | Johan Vande Voorde |Rory T. Steven |Arafath K. Najumudeen |Chelsea J. Nikula |Yuchen Xiang |Lauren Ford | +22 more

AbstractThe genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models, and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine.

Mar 12, 2023 | biorxiv.org | Johan Vande Voorde |Arafath K. Najumudeen |Rory T. Steven |Chelsea J. Nikula

New Results doi: https://doi.org/10.1101/2023.03.12.531945 AbstractWith colorectal cancer (CRC) being the second most common cause of cancer-related deaths worldwide, there is an urgent need for better diagnostic tools and new, more targeted therapies. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of common genetic drivers of CRC on the metabolic landscape of the intestine.