Johanna Trommer

Apr 12, 2024 | onlinelibrary.wiley.com | Johannes Buchner |Hristo L. Svilenov |Johanna Trommer |Florian Lesniowski

1 INTRODUCTION In most mammalian antibodies, the complementarity-determining regions (CDRs) from both the heavy chain (HC) and the light chain (LC) form the antigen-binding site. There are only a few exceptions to this paradigm such as the HC-only antibodies in camelids (Hamers-Casterman et al., 1993) and the antibodies with ultra-long CDR-H3s in cattle (Wang et al., 2013).