Johannes Buchner

Jan 17, 2025 | shorturl.at | Klaus Mayer |Raffael Schaffrath |Johannes Buchner |Lars Kaduhr

Abbreviations ACP, 3-amino-3-carboxypropyl group CCT/TriC, T-complex protein Ring Complex DPH1-8, protein/enzyme necessary for diphthamide synthesis 1–8 eEF2, eukaryotic translation elongation factor 2 HSP, heat shock protein Diphthamide on eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis [[1-3]]. Ribosomes that harbor eEF2 without diphthamide can generate mistranslated proteins due to higher incidences of −1 translational frameshifts [[4-6]].

Aug 29, 2024 | aanda.org | Johannes Buchner

Home All issues Volume 689 (September 2024) A&A, 689 (2024) L2 Full HTML Issue A&A Volume 689, September 2024 Article Number L2 Number of page(s) 5 Section Letters to the Editor DOI https://doi.org/10.1051/0004-6361/202451170 Published online 30 August 2024 A&A, 689, L2 (2024) Letter to the Editor Impediments to the cosmic growth of galaxies: The outflow budget from Star Formation and Active Galactic Nuclei ,⋆ Max Planck Institute for Extraterrestrial Physics, Giessenbachstrasse, 85741...

May 3, 2024 | jbc.org | Andreas Maier |Johannes Buchner

AbstractPosttranslational modifications of Hsp90 are known to regulate its in-vivo chaperone functions. Here we demonstrate that the lysine acetylation-deacetylation dynamics of Hsp82 is a major determinant in DNA repair mediated by Rad51. We uncover that the deacetylated lysine 27 in Hsp82 dictates the formation of the Hsp82-Aha1-Rad51 complex, which is crucial for client maturation.

Apr 12, 2024 | onlinelibrary.wiley.com | Johannes Buchner |Hristo L. Svilenov |Johanna Trommer |Florian Lesniowski

1 INTRODUCTION In most mammalian antibodies, the complementarity-determining regions (CDRs) from both the heavy chain (HC) and the light chain (LC) form the antigen-binding site. There are only a few exceptions to this paradigm such as the HC-only antibodies in camelids (Hamers-Casterman et al., 1993) and the antibodies with ultra-long CDR-H3s in cattle (Wang et al., 2013).