John A. Katzenellenbogen

Aug 17, 2023 | nature.com | Anastasia Sacharidou |Shashank R. Sirsi |John A. Katzenellenbogen |Andrew Lemoff |Chao Xing |Chieko Mineo

AbstractThe estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to influence relative obesity, and processes in adipose tissue and skeletal muscle that impact glucose control. Here we show that independent of impact on events in adipose tissue, endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle.