Andrew Lemoff

Nov 25, 2024 | nature.com | Amika Singla |Ran Song |Daniel Kramer |Andrew Lemoff |Xiaochen Bai |Zhe Chen | +2 more

AbstractDuring endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.

Nov 25, 2024 | nature.com | Amika Singla |Ran Song |Daniel Kramer |Andrew Lemoff |Xiaochen Bai |Zhe Chen | +2 more

AbstractDuring endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction have remained elusive. Here, we provide biochemical, structural, cellular, and proteomic analyses of the SNX17-Retriever interaction.

May 20, 2024 | nature.com | Emily Parks |Jiwoong Kim |Andrew Lemoff |Lin Xu |Jerry W. Shay |Ralph J. DeBerardinis | +1 more

AbstractCancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to target the destruction of cancer cells. We find that MYC-driven liver tumors rely on augmented tryptophan (Trp) uptake, yet Trp utilization to generate metabolites in the kynurenine (Kyn) pathway is reduced.

Aug 17, 2023 | nature.com | Anastasia Sacharidou |Shashank R. Sirsi |John A. Katzenellenbogen |Andrew Lemoff |Chao Xing |Chieko Mineo

AbstractThe estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to influence relative obesity, and processes in adipose tissue and skeletal muscle that impact glucose control. Here we show that independent of impact on events in adipose tissue, endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle.