John A Snowden

May 13, 2024 | onlinelibrary.wiley.com | John A Snowden

BOOK REVIEW Life Blood: Stories of Leukaemia Patients and their Doctorby Professor David Marks, Austin Macauley Publishers, 2024. pp. 177. ISBN: 978-1-0358336-8-9 First published: 13 May 2024 No abstract is available for this article.

May 2, 2024 | onlinelibrary.wiley.com | Vanessa Halliday |John A Snowden |Guruprasad P. Aithal

INTRODUCTION Haematopoietic cell transplantation (HCT) is a procedure used to treat malignant and non-malignant haematological disorders.

Jan 8, 2024 | nature.com | Gordon Cook |David Cairns |John A Snowden

Minimal residual disease (MRD) is a reproducible and independent predictor of both progression-free (PFS) and overall (OS) survival in multiple myeloma [1]. These data along with ever improving survival outcomes has led to consideration of MRD as a potential surrogate end point for regulatory purposes and an appropriate endpoint in academic studies which could accelerate evaluation of novel agents [2].

Jul 6, 2023 | nature.com | Eleanor J. Barnes |Carl S. Goodyear |Michelle Willicombe |Stefan Siebert |John A Snowden |Peter Kelleher | +3 more

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike antibodies, with an additional 600 of 2,204 (27%) patients generating low levels (<380 AU ml−1).

May 9, 2023 | nature.com | Meral Beksac |Patrice Chevallier |John A Snowden |Monika Engelhardt |Donal McLornan |Patrick J. Hayden | +1 more

AbstractEarly relapse (ER) following Autologous Hematopoietic Cell Transplantation (AHCT) confers a poor prognosis. We therefore developed a novel scoring system to predict ER. A total of 14,367 AHCT-1 patients were transplanted between 2014 and 2019, and were conditioned with Melphalan 200 mg/m2 (Mel200) (n = 7228; 2014–2017) (training cohort); Mel200 (n = 5616; 2018–2019) or Mel140 (n = 1523; 2018–2019) (validation cohorts).