John Hardy

3 weeks ago | biorxiv.org | Christine Lim |John Hardy |Michele Vendruscolo

AbstractAmyloid plaques and neurofibrillary tangles are molecular hallmarks of Alzheimer's disease. According to the amyloid cascade hypothesis, aberrant Aβ and tau behaviours contribute synergistically to accelerate the Alzheimer's pathology. However, the complex molecular mechanisms linking Aβ and tau dysregulation remain to be fully characterised. To address this problem, we investigated the connection between Aβ and tau through the protein homeostasis (proteostasis) network.