John Manalastas

Aug 1, 2024 | biorxiv.org | Ross M. Kedl |Scott Thompson |Michael Harbell |John Manalastas

AbstractProtection from pathogens relies on both humoral (antibody-mediated) and cellular (T cell-mediated) responses. While infections robustly elicit both types of immunity, currently approved vaccine adjuvants largely fail to induce T cell responses on par with that instigated by infections. Our goal was to investigate the transcriptional programming that supports the formation of CD8+ T cells elicited by subunit vaccines compared to those elicited by infections.