Ross M. Kedl

Aug 1, 2024 | biorxiv.org | Ross M. Kedl |Scott Thompson |Michael Harbell |John Manalastas

AbstractProtection from pathogens relies on both humoral (antibody-mediated) and cellular (T cell-mediated) responses. While infections robustly elicit both types of immunity, currently approved vaccine adjuvants largely fail to induce T cell responses on par with that instigated by infections. Our goal was to investigate the transcriptional programming that supports the formation of CD8+ T cells elicited by subunit vaccines compared to those elicited by infections.

Jul 10, 2023 | nature.com | Ross M. Kedl |Stephen C Jameson

CD8+ virtual memory T cells have been studied mainly for their antimicrobial functions but it seems that their descendants can contribute to inflammation and hair loss in the context of alopecia areata. The traditional conception of memory T cells is as the product of a response to foreign antigens. However, cells with memory-like properties also arise during normal T cell homeostasis.