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1 week ago | 
contagionlive.com | John Parkinson |Jatin M Vyas
Globally, more than 6.5 million people contract fungal infections annually, according to a systematic review published last year in The Lancet Infectious Diseases.1 There are 3.8 million deaths with about 2.5 million of them directly attributable to these infections.1 The rise of these infections and consequently resistance can be contributed to factors such as the widespread use of fungicides in agriculture, climate change, fungal species’ ability to develop resistant mechanisms, and limited...
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2 weeks ago | 
contagionlive.com | John Parkinson
The FDA has expanded the approval of Moderna’s mRNA-1345 RSV vaccine to include people aged 18-59 years.
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3 weeks ago | 
contagionlive.com | John Parkinson |Andrew S. Handel
With the warm weather brings the return of people being outside and the possibility of contracting tick-borne diseases. According to the Centers for Disease Control and Prevention (CDC), more than 89,000 cases of Lyme disease were reported in 2023 by state health departments and the District of Columbia. However, these numbers come from routine national surveillance and may underrepresent the actual burden.
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3 weeks ago | 
contagionlive.com | John Parkinson
June 5, 2025Mycovia Pharmaceuticals is evaluating oteseconazole against the standard of care for treating cryptococcal meningitis.
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3 weeks ago | 
contagionlive.com | John Parkinson |Sean Van Helden
In a new study presented at MAD-ID, omadacycline was found to have an 86% clinical success rate across a wide-range of infections and pathogens in an immunocompromised population. “This is an effective antibiotic, particularly in this patient population,” study investigator Sean Van Helden, PharmD, Postdoctoral Infectious Diseases Pharmacotherapy fellow, Wayne State University, said.
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3 weeks ago | 
contagionlive.com | John Parkinson |William Schaffner
Last week, the leaders of the National Institutes of Health, Health and Human Services, and FDA, announced the removal of the COVID-19 vaccine from the CDC immunization schedule for pregnant women and healthy children in a video social media post. "I couldn't be more pleased to announce that, as of today, the COVID-19 vaccine for healthy children and healthy pregnant women has been removed from the CDC recommended immunization schedule," Kennedy said in the video.
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4 weeks ago | 
contagionlive.com | John Parkinson
May 31, 2025The company's vaccine, mRNA-1283, becomes the first approval under the new federal guidelines. The federal agency has given the nod to the latest Moderna COVID-19 vaccine mRNA-1283 (mNEXSPIKE). This becomes the first vaccine approved under the new federal guidelines that change who is eligible for the immunizations.
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4 weeks ago | 
contagionlive.com | John Parkinson
This week, Moderna announced the Department of Health and Human Services (HHS) terminated the company's award for late-stage development of an avian influenza (H5) vaccine. In the award termination statement, Moderna also announced positive interim data from its phase 1/2 clinical study evaluating the safety and immunogenicity of its investigational vaccine, mRNA-1018.1Despite this news, Moderna plans to explore alternatives for late-stage development and manufacturing of the H5 program.
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1 month ago | 
contagionlive.com | John Parkinson
In a study being presented at MAD-ID, oral cephalosporins were found to be non-inferior to oral penicillins for the treatment of gram-negative Enterobacterales bloodstream infections. “Step-down therapy with oral cephalosporins was non-inferior to step-down with oral penicillins for treatment failure (7.1% vs. 7.1%; 95% CI [-0.064, 0.064], p = 0.002),” the investigators wrote.
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1 month ago | 
contagionlive.com | John Parkinson
In new research being presented at this week’s MAD-ID meeting, a large 2-year study reveals that the majority of patients seen in outpatient facilities for sinusitis-related complaints were prescribed antibiotics. Of more than 37,000 primary care encounters, 79% of patients received a prescription for this class of medication.
