Contagion Live

Contagion® serves as a comprehensive news platform dedicated to all aspects of infectious diseases. Our offerings include a website, a quarterly journal, email newsletters, social media updates, and the Outbreak Monitor. These resources deliver targeted information to healthcare professionals and specialists, aimed at enhancing patient care and aiding in the identification, diagnosis, treatment, and prevention of infectious diseases. Our goal is to empower both the healthcare community and the public with valuable knowledge, enabling better decision-making that positively influences patient outcomes.

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Precision in Practice: PK/PD Modeling Advances Infectious Disease Care

4 days ago | contagionlive.com | Sophia Abene |Marc H. Scheetz

At the 2025 MAD-ID meeting, Mark Sheets, PharmD, MSc, professor of pharmacy and pharmacology at Midwestern University and director of the Pharmacometrics Center of Excellence, facilitated a conversation about the evolving role of pharmacokinetic/pharmacodynamic (PK/PD) modeling in infectious diseases, and why its clinical relevance is only just beginning to take hold.
Federal Government Changes Course Again on COVID-19 Vaccine Policy

5 days ago | contagionlive.com | John Parkinson |William Schaffner

Last week, the leaders of the National Institutes of Health, Health and Human Services, and FDA, announced the removal of the COVID-19 vaccine from the CDC immunization schedule for pregnant women and healthy children in a video social media post. "I couldn't be more pleased to announce that, as of today, the COVID-19 vaccine for healthy children and healthy pregnant women has been removed from the CDC recommended immunization schedule," Kennedy said in the video.
Trimethoprim/Sulfamethoxazole and Minocycline Show Comparable Outcomes in Stenotrophomonas maltophilia Pneumonia

5 days ago | contagionlive.com | Sophia Abene

A retrospective single-center chart review presented at MAD-ID 2025 by Kimberly Leuthner, PharmD, FIDSA, evaluated the use of trimethoprim/sulfamethoxazole (TMP/SMX) versus minocycline for the treatment of Stenotrophomonas maltophilia pneumonia and found no difference in clinical outcomes between the two antibiotics. The study, conducted at Sunrise Hospital and University Medical Center of Southern Nevada, included adult patients with respiratory cultures growing only S maltophilia.
FDA Approves Moderna’s COVID-19 Vaccine

1 week ago | contagionlive.com | John Parkinson

May 31, 2025The company's vaccine, mRNA-1283, becomes the first approval under the new federal guidelines. The federal agency has given the nod to the latest Moderna COVID-19 vaccine mRNA-1283 (mNEXSPIKE). This becomes the first vaccine approved under the new federal guidelines that change who is eligible for the immunizations.
Oral Vancomycin "Tail" Offers No Added Benefit for CDI Prophylaxis

1 week ago | contagionlive.com | Sophia Abene |Jiye Park

A study presented at MAD-ID 2025 by Jennifer (Jiye) Park, PharmD, evaluated the clinical utility of oral vancomycin as secondary prophylaxis for Clostridioides difficile infection (CDI) and found no statistically significant benefit in extending its use beyond the completion of systemic antibiotics. The retrospective analysis, conducted at Massachusetts General Hospital between January 1 and December 31, 2022, included 163 adult inpatient encounters.
Advancing C diff Management: Fidaxomicin, Microbiome Therapies, and Stewardship

1 week ago | contagionlive.com | Sophia Abene |Rachel M. Kenney

At MAD-ID 2025, Rachel M Kenney, PharmD, served as a facilitator for the accredited continuing education session, “Improving Outcomes in C difficile.” The session focused on current guideline updates, emerging treatment strategies, and the critical role of stewardship in managing C difficile infections. Kenney spoke about key changes in how clinicians are approaching C diff, especially in the context of first-line treatment and microbiome-focused therapies.
HHS Cancels Moderna’s Award for Developing Avian Influenza Vaccine

1 week ago | contagionlive.com | John Parkinson

This week, Moderna announced the Department of Health and Human Services (HHS) terminated the company's award for late-stage development of an avian influenza (H5) vaccine. In the award termination statement, Moderna also announced positive interim data from its phase 1/2 clinical study evaluating the safety and immunogenicity of its investigational vaccine, mRNA-1018.1Despite this news, Moderna plans to explore alternatives for late-stage development and manufacturing of the H5 program.
Oral Cephalosporins Safe, Effective For Step-Down Therapy For Gram-negative Bloodstream Infections

1 week ago | contagionlive.com | John Parkinson

In a study being presented at MAD-ID, oral cephalosporins were found to be non-inferior to oral penicillins for the treatment of gram-negative Enterobacterales bloodstream infections. “Step-down therapy with oral cephalosporins was non-inferior to step-down with oral penicillins for treatment failure (7.1% vs. 7.1%; 95% CI [-0.064, 0.064], p = 0.002),” the investigators wrote.
Antibiotic Practices For Sinusitis in Outpatient Settings Suggest Overprescribing

1 week ago | contagionlive.com | John Parkinson

In new research being presented at this week’s MAD-ID meeting, a large 2-year study reveals that the majority of patients seen in outpatient facilities for sinusitis-related complaints were prescribed antibiotics. Of more than 37,000 primary care encounters, 79% of patients received a prescription for this class of medication.
Integrating AI into Pharmacy Education and Stewardship

1 week ago | contagionlive.com | Sophia Abene |Timothy Aungst

Artificial intelligence (AI) is playing an increasing role in healthcare practice and professional education. Timothy Aungst, PharmD, professor of pharmacy practice at the Massachusetts College of Pharmacy and Health Sciences in Worcester, Massachusetts, discussed the use of AI in stewardship education during his keynote presentation, “Digital Health and Infectious Diseases,” at MAD-ID 2025 in Orlando, Florida.