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2 months ago | 00060-6&sz=64)
cell.com | Naomi Wilcox |Jonathan P Tyrer |Joe Dennis |Xin Yang |John Perry |Eugene J. Gardner | +1 more
Keywordsheritabilitygeneticscancerrare variantsexomeburdenprotein-truncating variantsIntroductionGenome-wide association studies (GWASs) have been highly successful at identifying common variants associated with disease. Increasingly, association studies are being extended to study rare variants using next-generation sequencing methods.
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Feb 7, 2025 | 
eastoregonian.com | John Perry
Personalised advertising and content, advertising and content measurement, audience research and services developmentStore and/or access information on a deviceYou can choose how your personal data is used.
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Aug 21, 2024 | 
insidehousing.co.uk | John Perry
Comment As councils defer housebuilding due to dire financial straits, John Perry, policy advisor at the Chartered Institute of Housing, looks at potential investment plans Sharelines As councils defer housebuilding due to dire financial straits, John Perry, policy advisor at the Chartered Institute of Housing, looks at potential investment plans #UKhousing News that three London councils have deferred new housebuilding projects was another of the red flags that signal the worrying state of...
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Apr 17, 2024 | 
insidehousing.co.uk | John Perry
You are viewing 1 of your 1 free articlesCommentHow should social landlords respond to rising migration and government migration policy, asks John Perry, policy advisor at the Chartered Institute of HousingJohn Perry is also a contributing editor of the UK Housing Review seriesSharelinesHow does increased migration affect housing providers?
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Mar 6, 2024 | 
insidehousing.co.uk | John Perry
CommentJohn Perry, policy advisor at the Chartered Institute of Housing, looks at the historical precedent for increasing affordable housebuilding grantsSharelinesWhy not fund affordable housing through extra borrowing?
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Feb 6, 2024 | 
nature.com | Jiayi Xie |John Perry |Shuan Rao |Xunlei Kang |Meng Zhao
AbstractLeukaemia stem cells (LSCs) in acute myeloid leukaemia present a considerable treatment challenge due to their resistance to chemotherapy and immunosurveillance. The connection between these properties in LSCs remains poorly understood. Here we demonstrate that inhibition of tyrosine phosphatase SHP-1 in LSCs increases their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability to immunosurveillance.
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Nov 26, 2023 | 
nasenjournals.onlinelibrary.wiley.com | John Perry
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Oct 18, 2023 | 
jdsupra.com | John Perry
There are two primary ways to structure the taxable purchase and sale of an incorporated business. The parties may engage in an asset acquisition, in which the buyer purchases assets directly from the target corporation. Alternatively, the parties may engage in a stock sale, in which the buyer purchases the target corporation's stock directly from the selling shareholders.
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Oct 10, 2023 | 
fg.bmj.com | David Nylander |John S Leeds |John Perry |Manjusha Narayanan
Discussion There have been suggestions that endoscopists are at minimal risk of facial contamination performing GI endoscopy procedures, so face shields are not required.8 A study comparing contamination of endoscopist face shields during upper GI endoscopy in patients in left lateral versus prone position showed greater contamination of face shields in the left lateral position, but contamination in the face shields was deemed not clinically meaningful.9 Our study is the first to investigate...
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Aug 17, 2023 | 
nature.com | Eugene J. Gardner |Heiko Becher |Sabine Behrens |Thilo Dörk |Pascal Guénel |Jingmei Li | +14 more
AbstractLinkage and candidate gene studies have identified several breast cancer susceptibility genes, but the overall contribution of coding variation to breast cancer is unclear. To evaluate the role of rare coding variants more comprehensively, we performed a meta-analysis across three large whole-exome sequencing datasets, containing 26,368 female cases and 217,673 female controls.
