John Perry

Feb 6, 2024 | nature.com | Jiayi Xie |John Perry |Shuan Rao |Xunlei Kang |Meng Zhao

AbstractLeukaemia stem cells (LSCs) in acute myeloid leukaemia present a considerable treatment challenge due to their resistance to chemotherapy and immunosurveillance. The connection between these properties in LSCs remains poorly understood. Here we demonstrate that inhibition of tyrosine phosphatase SHP-1 in LSCs increases their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability to immunosurveillance.

Nov 26, 2023 | nasenjournals.onlinelibrary.wiley.com | John Perry

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Oct 18, 2023 | jdsupra.com | John Perry

There are two primary ways to structure the taxable purchase and sale of an incorporated business. The parties may engage in an asset acquisition, in which the buyer purchases assets directly from the target corporation. Alternatively, the parties may engage in a stock sale, in which the buyer purchases the target corporation's stock directly from the selling shareholders.

Oct 10, 2023 | fg.bmj.com | David Nylander |John S Leeds |John Perry |Manjusha Narayanan

Discussion There have been suggestions that endoscopists are at minimal risk of facial contamination performing GI endoscopy procedures, so face shields are not required.8 A study comparing contamination of endoscopist face shields during upper GI endoscopy in patients in left lateral versus prone position showed greater contamination of face shields in the left lateral position, but contamination in the face shields was deemed not clinically meaningful.9 Our study is the first to investigate...

Aug 17, 2023 | nature.com | Eugene J. Gardner |Heiko Becher |Sabine Behrens |Thilo Dörk |Pascal Guénel |Jingmei Li | +14 more

AbstractLinkage and candidate gene studies have identified several breast cancer susceptibility genes, but the overall contribution of coding variation to breast cancer is unclear. To evaluate the role of rare coding variants more comprehensively, we performed a meta-analysis across three large whole-exome sequencing datasets, containing 26,368 female cases and 217,673 female controls.