John Silke

Nov 25, 2024 | febs.onlinelibrary.wiley.com | Lin Liu |John Silke

Conflict of interest The authors declare no conflict of interest. References 1 & (2018) Wnt signaling in development and tissue homeostasis. Development 145, dev146589. 2, , & (2019) An aggregon in conductin/axin2 regulates Wnt/beta-catenin signaling and holds potential for cancer therapy. Nat Commun 10, 4251. 3, , , , , , , , , et al. (2002) Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22, 1184–1193.

Apr 12, 2024 | nature.com | Hirotsugu Oda |Kalpana Manthiram |Pallavi Pimpale Chavan |Shuichiro Nakabo |Mariël Swart |Nisa Celik | +22 more

AbstractThe linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death.

Apr 10, 2024 | nature.com | John Silke

NEWS AND VIEWS 10 April 2024 Animals that receive an inhibitor of an antiviral cell-death response called necroptosis are less likely to die of influenza even at a late stage of infection. This has implications for the development of therapies for respiratory diseases. If there is one lesson to be learnt from the pandemic, it is that we need to be better prepared for the next one. Influenza pandemics have killed millions in the past and could do so again.