John Soltys

Jan 13, 2025 | cell.com | Yahel Segal |John Soltys |Benjamin D.S. Clarkson |Charles Howe |Sarosh R Irani |Sean J. Pittock

(A) Despite its description as an immune-privileged site, a growing body of knowledge reveals that the CNS is subject to immune surveillance and immune tolerance. CNS antigens drain via the glymphatic system into venous dural sinuses and ultimately cervical lymph nodes (i), where they are presented to lymphocytes and APCs (ii). In a healthy tolerogenic state, autoreactive lymphocytes are then tolerized through peripheral tolerance mechanisms.