Sarosh R Irani

Jan 13, 2025 | cell.com | Yahel Segal |John Soltys |Benjamin D.S. Clarkson |Charles Howe |Sarosh R Irani |Sean J. Pittock

(A) Despite its description as an immune-privileged site, a growing body of knowledge reveals that the CNS is subject to immune surveillance and immune tolerance. CNS antigens drain via the glymphatic system into venous dural sinuses and ultimately cervical lymph nodes (i), where they are presented to lymphocytes and APCs (ii). In a healthy tolerogenic state, autoreactive lymphocytes are then tolerized through peripheral tolerance mechanisms.

Feb 29, 2024 | tribunecontentagency.com | Sarosh R Irani

Understanding encephalitis: Symptoms, causes and treatment Mayo Clinic Q&A   February 29, 2024 By Sarosh Irani, B.M.B.Ch., D.Phil., Mayo Foundation for Medical Education and ResearchEncephalitis is a rare disease. (Dreamstime/TNS)DEAR MAYO CLINIC: Ever since I had my son, I tend to worry whenever he gets ill, so I try to educate myself on different viruses and autoimmune disorders. I recently came across encephalitis. What is it? What are some of the warning signs? And how is it treated?

Jan 16, 2024 | jamanetwork.com | Adam E. Handel |Oxford Hospitals |Sarosh R Irani

MOG-IgA as a Potential Marker of Germinal Center Activity Myelin Oligodendrocyte Glycoprotein–IgA in a Subgroup of Patients With Central Nervous System Demyelination Ana Beatriz Ayroza Galvão Ribeiro Gomes, MD; Laila Kulsvehagen, MSc; Patrick Lipps, MD; Alessandro Cagol, MD; Nuria Cerdá-Fuertes, MD; Tradite Neziraj, MD; Julia Flammer, MD; Jasmine Lerner; Anne-Catherine Lecourt, MSc; Nina de Oliveira S.

Dec 26, 2023 | jamanetwork.com | Adrian Budhram |Sarosh R Irani |Eoin P. Flanagan

Looking Beyond Syndrome-Based Criteria for Autoimmune Encephalitis—The Need for Complementary Neural Antibody–Based Diagnostic Criteria Encephalitis classically presents as a syndrome of rapidly progressive encephalopathy with memory deficits, altered mental status, and/or psychiatric symptoms.1 Syndrome-based criteria for autoimmune encephalitis (AE) were proposed as part of a diagnostic algorithm and help clinicians navigate differential diagnoses while awaiting antibody results.1 With use...

Apr 17, 2023 | physiciansweekly.com | Ali M Alam |Ava Easton |Timothy R. Nicholson |Sarosh R Irani

Encephalitis describes inflammation of the brain parenchyma, typically caused by either an infectious agent or through an autoimmune process which may be postinfectious, paraneoplastic or idiopathic. Patients can present with a combination of fever, alterations in behaviour, personality, cognition and consciousness. They may also exhibit focal neurological deficits, seizures, movement disorders and/or autonomic instability.