Johnson Ying

Aug 19, 2024 | cell.com | Jennifer Robinson |Johnson Ying |Michael E. Hasselmo |Mark Brandon

Highlights•Medial septum (MS)-GABAergic inhibition reduces theta rhythms•MS-GABAergic inhibition disrupts grid cell spatial periodicity and theta phase precession•Theta rhythm is restored immediately after MS-GABAergic inhibition•Grid cell spatial coding takes longer (60 s) to recover from MS-GABAergic inhibitionSummaryThe hippocampus and medial entorhinal cortex (MEC) form a cognitive map that facilitates spatial navigation.

Nov 10, 2023 | biorxiv.org | Jennifer Robinson |Johnson Ying |Michael E. Hasselmo |Mark Brandon

AbstractThe hippocampus and medial entorhinal cortex (MEC) form a cognitive map that facilitates spatial navigation. As part of this map, MEC grid cells fire in a repeating hexagonal pattern across an environment. This grid pattern relies on inputs from the medial septum (MS). The MS, and specifically its GABAergic neurons, are essential for theta rhythm oscillations in the entorhinal-hippocampal network, however, it is unknown if this subpopulation is also essential for grid cell function.