Jonathan Chee

Dec 27, 2024 | cell.com | Wee Loong Chin |Jonathan Chee |Nicola Principe |Tracy Hoang |Joel Kidman |Yen Yeow | +23 more

Keywordsimmune checkpoint therapyICTplatinum chemotherapymesotheliomasingle-cell RNA sequencingbiomarkersresponseperipheral bloodcancerCD8+ T effector memory cellsPD-L1IntroductionPleural mesothelioma is a rare malignancy linked to asbestos exposure. Mesothelioma is often advanced at diagnosis and carries a poor prognosis, with patients surviving approximately 12–15 months despite treatment, which for decades has been platinum-based chemotherapy.1 However, the treatment paradigm is changing.