Nicola Principe

Dec 27, 2024 | cell.com | Wee Loong Chin |Jonathan Chee |Nicola Principe |Tracy Hoang |Joel Kidman |Yen Yeow | +23 more

Keywordsimmune checkpoint therapyICTplatinum chemotherapymesotheliomasingle-cell RNA sequencingbiomarkersresponseperipheral bloodcancerCD8+ T effector memory cellsPD-L1IntroductionPleural mesothelioma is a rare malignancy linked to asbestos exposure. Mesothelioma is often advanced at diagnosis and carries a poor prognosis, with patients surviving approximately 12–15 months despite treatment, which for decades has been platinum-based chemotherapy.1 However, the treatment paradigm is changing.

Sep 1, 2024 | jitc.bmj.com | Nicola Principe |Ben Wylie |Amber-Lee Phung |Omar Elaskalani

Materials and methodsBALB/c and C57BL/6 mice (RRID: IMSR_ARC:BC, RRID: IMSR_ARC:B6) were bred and maintained at the Animal Resources Centre (Murdoch, Western Australia, Australia) or Harry Perkins Institute of Medical Research (Murdoch and Nedlands, Western Australia, Australia).