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2 weeks ago | 
biorxiv.org | John Janetzko |Jonathan Deutsch |Yuqi Shi |Dirk H. Siepe
AbstractArrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GPCR internalization and trafficking. While there are hundreds of diverse GPCRs, only two β-arrestin isoforms (βarrs) must recognize and engage this wide range of receptors with varied phosphorylation patterns.
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3 weeks ago | 
theinfatuation.com | Jonathan Deutsch
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4 weeks ago | 
theinfatuation.com | Jonathan Deutsch
What are you looking for?
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1 month ago | 
theinfatuation.com | Jonathan Deutsch
Philly is rich with Ethiopian restaurants: Abyssinia, Dahlak, and Doro Bet, to name a few. The same cannot be said for the Main Line—Eshkol has the distinction of being the only game in town. From the silkscreened decorative tablecloths and wicker lampshades to the vast assortment of soaps and hand lotions in the restroom, it is a charming love letter of a restaurant. The hospitality and food give you the feeling of being invited to an Ethiopian family dinner.
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1 month ago | 
theinfatuation.com | Jonathan Deutsch
Carina Sorella, which translates to “cute sister,” is the perfect name for the Bryn Mawr sibling of Fitler Square’s charming Trattoria Carina. Visually, she is darling. A sprawling L-shaped dining room with green tile, blonde wood and marble patterned tables transports you out of the neighborhood and straight to an Italian Pinterest board. But this group, which also operates the beloved Pub & Kitchen in Rittenhouse and The Diving Horse in Avalon, treats the suburbs with less care.
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1 month ago | 
theinfatuation.com | Jonathan Deutsch
Don’t let the name fool you–this is not a funeral home or law firm. This Haverford bar has been a reliable place to slink in for a shot, a beer, and a burger since 1933. Well-worn woodwork, historic photos and taxidermied local wildlife (which doubles as the restaurant’s racoon mascot) gives you the sense that this kitsch is the real deal, not the phony flair of a chain restaurant. The food and service confirm the authenticity.
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1 month ago | 
theinfatuation.com | Jonathan Deutsch
When a restaurant calls itself a Mediterranean kitchen, do they mean they cook everything from Spanish cuisine to Middle Eastern? In Dua’s case, yes. Luckily for Bryn Mawr locals, the Albanian-owned BYOB leans most heavily into its Balkan identity. Its flavors are influenced by neighboring Greece, Italy and the Balkan States—think olives, feta, lemon, and garlic—with a touch of soviet-era bluntness still lingering.
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1 month ago | 
plateonline.com | Jonathan Deutsch
In this era of high-profile influencer events, paid search term buys, and PR contracts that eat up as much budget as the rent for a restaurant, it may be easy to forget that a marketing campaign can run in the two-figures.
Aaron Gordon, owner of pizza shop Agricola in Philadelphia, tripled his Sunday revenue for the cost of fifteen blocks of wood and some comped pizzas in a campaign he calls “... Join for free to continue reading.
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1 month ago | 
theinfatuation.com | Jonathan Deutsch
Sure, we get that recommending the best barbecue joint in the Philadelphia suburbs is like recommending the best Philly cheesesteak in Des Moines. But La Cabra in Bryn Mawr has legit barbecue smoked in-house, served alongside eleven of their own beers from their nearby Berwyn brewpub, along with cider and rotating draft cocktails.
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1 month ago | 
theinfatuation.com | Jonathan Deutsch
Narberth is a quaint little town without much of a food scene to speak of. But Little Blue Owl is the real deal—a French bakery that’ll have you singing the praises of its croissants, Beauty & The Beast-style as you drive down Haverford Ave. Except for a few outdoor tables, it’s takeout only, so pop in to make your morning commute more palatable or to fuel your weekend errands.
