Yuqi Shi

2 weeks ago | biorxiv.org | John Janetzko |Jonathan Deutsch |Yuqi Shi |Dirk H. Siepe

AbstractArrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GPCR internalization and trafficking. While there are hundreds of diverse GPCRs, only two β-arrestin isoforms (βarrs) must recognize and engage this wide range of receptors with varied phosphorylation patterns.