Jonathan M. E

Sep 24, 2023 | dx.doi.org | Jonathan M. E |Lucy A. Harwood |Kirsten Christensen |Ziyue Xiong

Cyclobutyl amino alcohols are versatile synthetic intermediates whose derivatives feature in medicinal chemistry as key components in pharmaceutical candidates, (1) as motifs for exploring QSAR models and in lead/fragment-based drug discovery, (2) and as sp3-rich bioisosteric replacements for their aryl counterparts. (3) Despite this, there are few general methods for producing such compounds, particularly in an enantiomerically enriched form.