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Jul 8, 2024 | 
nature.com | Yaseen A. Almehmadi |Kirsten Christensen |Ken Yamazaki |Nandini J. Guzman
AbstractThree-dimensional nitrogen-rich bridged ring systems are of great interest in drug discovery owing to their distinctive physicochemical and structural properties. However, synthetic approaches towards N–N-bond-containing bridged heterocycles are often inefficient and require tedious synthetic strategies.
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Jun 27, 2024 | 
digitalcommons.library.tmc.edu | Yan Zhang |F Wieland Goetzke |Kirsten Christensen |Stephen Fletcher
Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here, we report Rh-catalyzed asymmetric Suzuki–Miyaura-type cross-coupling reactions between a racemic N-Boc-nortropane-derived allylic chloride and (hetero)aryl boronic esters. The reaction proceeds via an unexpected kinetic resolution, and the resolved enantiopure allyl chloride can undergo highly enantiospecific reactions with N-, O-, and S-containing nucleophiles.
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Dec 14, 2023 | 
dx.doi.org | Jiarui Zong |Kirsten Christensen |Jeremy Robertson |Parois Pascal
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Lett. 2024, XXXX, XXXRETURN TO ARTICLES ASAPPREVLetterNEXTJiarui ZongDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom, Kirsten E. ChristensenDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom, and *Cite this: Org. Lett. 2024, XXXX, XXX.
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Dec 6, 2023 | 
onlinelibrary.wiley.com | Daniel Rozsar |Jinchao Yang |Kirsten Christensen |Darren J. Dixon
Carboxamides are commonly occurring motifs in numerous natural products, biomolecules, and pharmaceuticals.
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Nov 29, 2023 | 
dx.doi.org | Ryan E. McNamee |Ayan Dasgupta |Kirsten Christensen |Edward A. Anderson
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Lett. 2023, XXXX, XXXRETURN TO ARTICLES ASAPPREVLetterNEXTRyan E. McNameeChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Ayan DasguptaChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Kirsten E.
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Nov 29, 2023 | 
pubs.acs.org | Ryan E. McNamee |Ayan Dasgupta |Kirsten Christensen |Edward A. Anderson
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Lett. 2023, XXXX, XXXRETURN TO ARTICLES ASAPPREVLetterNEXTRyan E. McNameeChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Ayan DasguptaChemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Kirsten E.
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Oct 25, 2023 | 
nature.com | Yueze Gao |Florian Albrecht |Kirsten Christensen |Ivano Tavernelli |Harry Anderson |Max Rossmannek
AbstractSynthetic carbon allotropes such as graphene1, carbon nanotubes2 and fullerenes3 have revolutionized materials science and led to new technologies. Many hypothetical carbon allotropes have been discussed4, but few have been studied experimentally. Recently, unconventional synthetic strategies such as dynamic covalent chemistry5 and on-surface synthesis6 have been used to create new forms of carbon, including γ-graphyne7, fullerene polymers8, biphenylene networks9 and cyclocarbons10,11.
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Oct 2, 2023 | 
pubs.rsc.org | Mariska de Munnik |Jasper Lithgow |Lennart Brewitz |Kirsten Christensen
αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes†
Epoxides are an established class of electrophilic alkylating agents that react with nucleophilic protein residues. We report αβ,α′β′-diepoxyketones (DEKs) as a new type of mechanism-based inhibitors of nucleophilic cysteine enzymes.
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Sep 28, 2023 | 
chemistry-europe.onlinelibrary.wiley.com | Philip Smith |Helena Pickford |Kirsten Christensen |Zixuan Tong
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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Sep 24, 2023 | 
dx.doi.org | Jonathan M. E |Lucy A. Harwood |Kirsten Christensen |Ziyue Xiong
Cyclobutyl amino alcohols are versatile synthetic intermediates whose derivatives feature in medicinal chemistry as key components in pharmaceutical candidates, (1) as motifs for exploring QSAR models and in lead/fragment-based drug discovery, (2) and as sp3-rich bioisosteric replacements for their aryl counterparts. (3) Despite this, there are few general methods for producing such compounds, particularly in an enantiomerically enriched form.
