Jonathan T. Vu

Dec 13, 2024 | ejog.org | Grace Freeman-Spratt |William Spratt |Jonathan T. Vu |Jan JA Bosteels |Ben W Mol

Abbreviations RCT (randomised control trial) TRACT (Trustworthiness in RAndomised Controlled Trials) Keywords Concerns have been raised about the trustworthiness of published RCTs about hysteroscopies Including rounded numbers of participants in each group Zero dropout Retrospective registration and papers by authors or institutions flagged for having retracted papers Introduction Trial registration for randomised controlled trials (RCTs) was introduced to mitigate the impact of publication...

Sep 12, 2024 | onlinelibrary.wiley.com | Jonathan T. Vu |Graham C. Haug |Yongxian Li |Biyu Zhao

Introduction Organoboron compounds represent one of the most versatile and widely utilized classes of reagents in organic synthesis.1 Unlike most types of organometallic reagents, common organoboron species, such as alkylboronic pinacol esters (APEs), are non-toxic, highly functional-group-tolerant, and bench-stable under ambient conditions.1b The synthesis of organoboron compounds, particularly APEs, is highly modular.2 The iterative homologation of APEs can rapidly and selectively introduce...

Feb 4, 2024 | biorxiv.org | Jonathan T. Vu |Katherine U Tavasoli |Lori Mandjikian |Connor J Sheedy

AbstractPeroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans, peroxisomes are required for normal development, yet the genes regulating peroxisome function remain unclear. We performed a genome-wide CRISPRi screen to identify novel factors involved in peroxisomal homeostasis. We found that inhibition of RNF146, an E3 ligase activated by poly(ADP-ribose), reduced the import of proteins into peroxisomes.