Jonathan Ward

May 21, 2024 | onlinelibrary.wiley.com | Jonathan Ward |Andrea Vezzoli |Charlie Wells |Steven Bailey

Introduction Our understanding of how to design molecules that efficiently conduct electricity across a nanogap in a molecular junction (metal-molecule-metal) configuration has increased dramatically in the past 15 years.1-7 The contact groups are a fundamental part of the design of molecular wires, providing chemical, mechanical and electronic coupling of the molecular species to the electrodes.

Jul 4, 2023 | jacc.org | Robert J. Mentz |Jonathan Ward |Adrian F. Hernandez |Adrián Hernández |Serge Lepage

JACC Journals › JACC › Archives › Vol. 82 No. 1 AbstractBackgroundU.S. guidelines recommend consideration of sacubitril/valsartan in chronic heart failure (HF) and mildly reduced or preserved ejection fraction (EF). Whether initiation is safe and effective in EF >40% after a worsening heart failure (WHF) event is unknown.

Feb 13, 2023 | onlinejcf.com | Robert J. Mentz |Jonathan Ward |Adrian F. Hernandez |Adrian Hernandez

Background PARAGON-HF studied the effect of sacubitril/valsartan (Sac/Val) compared with valsartan (Val) on clinical outcomes in patients with chronic heart failure with preserved ejection fraction (HFpEF) or mildly reduced EF (HFmrEF). Further data are needed regarding the use of Sac/Val in these EF groups with a recent worsening heart failure (WHF) event and in key populations not broadly represented in PARAGON-HF, including de novo HF, severely obese, and Black patients.