Jonathan Zhu

Jan 19, 2025 | jbc.org | Simone Hall |Jonathan Zhu |Lauren Ellis

KeywordsLong non-coding RNAmRNARNA binding proteinRNA-protein interactionmRNA stabilitygene expressionMALAT1TAR DNA-binding protein 43 (TDP-43) (TARDBP)neurodegenerationIntroductionRNA-protein interactions regulate gene expression, splicing, and cell growth. Genome-wide studies of RNA-protein interactions suggest that eukaryotic cells contain complex networks of binding interactions between RNAs and proteins, including mRNAs, non-coding RNAs, splicing factors and other RNA binding proteins.