Jordi Doijen

1 month ago | nature.com | Sofie Jacobs |Jordi Doijen |Rana Abdelnabi |Michiel Van Gool |Alexandra Schafer |Dirk Jochmans | +12 more

AbstractThe membrane (M) protein of betacoronaviruses is well conserved and has a key role in viral assembly1,2. Here we describe the identification of JNJ-9676, a small-molecule inhibitor targeting the coronavirus M protein. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and sarbecovirus strains from bat and pangolin zoonotic origin.