Jordi Heijman

Dec 28, 2023 | journals.physiology.org | Natalia A. Trayanova |Aurore Lyon |Julie K. Shade |Jordi Heijman

CLINICAL HIGHLIGHTSComputational modeling of the heart has become an important research tool in cardiac electrophysiology and arrhythmias, as it provides a link between effects at the subcellular level, including genetic mutations and protein function, and emergent electrophysiological phenomena at the organ level. Electrophysiological models of the heart are currently being employed in real-world applications in mechanistic research, safety pharmacology, and personalized therapy.

Jul 7, 2023 | frontiersin.org | Jordi Heijman

Cardiac diseases are the main cause of death worldwide and their incidence and prevalence are likely to increase because of ageing of the population and unhealthy changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset, encompass molecular and electrophysiological changes in the cardiac tissue and cells. Insights into the underlying molecular mechanisms are essential to create a deeper understanding of key concepts of cardiac disease development.