Jordi Merino

2 months ago | nature.com | Magdalena Sevilla-Gonzalez |Elizabeth Litkowski |Hyunkyung Kim |Ching-Ti Liu |Chenglong Yu |John McNeil | +12 more

AbstractElevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distinct mechanisms contributing to elevated FI levels.

2 months ago | digitalcommons.library.tmc.edu | Deirdre K Tobias |Jordi Merino |Abrar Ahmad |Catherine E Aiken

KeywordsHumans, Precision Medicine, Consensus, Diabetes Mellitus, Evidence-Based MedicineAbstractPrecision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely.

Jul 19, 2024 | nature.com | Zhila Semnani-Azad |Mario L. Morieri |John Dennis |Claudia Langenberg |Michèle Ramsay |Arun J Sanyal | +6 more

AbstractPrecision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous.

May 23, 2023 | nature.com | Jordi Merino |Hassan S Dashti |Marie-France Hivert |Richa Saxena

AbstractPrior research identified genetic variants influencing macronutrient preference, but whether genetic differences underlying nutrient preference affect long-term food choices is unknown. Here we examined the associations of polygenic scores for carbohydrate, fat, and protein preference with 12 months’ workplace food purchases among 397 hospital employees from the ChooseWell 365 study.