Ching-Ti Liu

1 month ago | nature.com | Magdalena Sevilla-Gonzalez |Elizabeth Litkowski |Hyunkyung Kim |Ching-Ti Liu |Chenglong Yu |John McNeil | +12 more

AbstractElevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distinct mechanisms contributing to elevated FI levels.

May 20, 2024 | digitalcommons.library.tmc.edu | Yixin Zhang |James B. Meigs |Ching-Ti Liu |Josée Dupuis

BACKGROUND: Considering relatives' health history in logistic regression for case-control genome-wide association studies (CC-GWAS) may provide new information that increases accuracy and power to detect disease associated genetic variants.

Jun 12, 2023 | onlinelibrary.wiley.com | Loraine Liping Seng |Ching-Ti Liu |Jingli Wang |Jialiang Li

1 INTRODUCTION Instrumental variable (IV) methods are frequently used to control for confounding and measurement error in observational studies. They allow for the possibility of making correct causal inferences with observational data. Historically IVs have primarily been used in economics research, but have recently begun to win favor in epidemiological and biostatistical studies.

Jun 8, 2023 | nature.com | Alice Williamson |Anne Jackson |Mette Andersen |Thomas Buchanan |Lee-Ming Chuang |Ren-Hua Chung | +43 more

Author notesThese authors jointly supervised this work: Karen L. Mohlke, Eleanor Wheeler, Stephen O’Rahilly, Daniel J. Fazakerley,Claudia Langenberg. Authors and AffiliationsMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UKAlice Williamson, Jian’an Luan, Nicholas J.