Joris L. Vos

3 weeks ago | nature.com | Joris L. Vos |Daniel Muldoon |Cristina Valero |Andrew Lee |Timothy Chan |Michael Berger | +1 more

AbstractTo understand genetic evolution in cancer during metastasis, we analyzed genomic profiles of 3,732 cancer patients in whom several tumor sites were longitudinally biopsied. During distant metastasis, tumors were observed to accumulate copy number alterations (CNAs) to a much greater degree than mutations. In particular, the development of whole genome duplication was a common event during metastasis, emerging de novo in 28% of patients.