Timothy Chan

3 weeks ago | nature.com | Joris L. Vos |Daniel Muldoon |Cristina Valero |Andrew Lee |Timothy Chan |Michael Berger | +1 more

AbstractTo understand genetic evolution in cancer during metastasis, we analyzed genomic profiles of 3,732 cancer patients in whom several tumor sites were longitudinally biopsied. During distant metastasis, tumors were observed to accumulate copy number alterations (CNAs) to a much greater degree than mutations. In particular, the development of whole genome duplication was a common event during metastasis, emerging de novo in 28% of patients.

1 month ago | nature.com | Chao Wang |Jamie K Teer |Xiaoxian Liu |Timothy Chan |Vladimir Makarov |Carmen Anadon | +6 more

AbstractCell therapy with tumor-infiltrating lymphocytes (TILs) has yielded durable responses for multiple cancer types, but the causes of therapeutic resistance remain largely unknown. Here multidimensional analysis was performed on time-serial tumor and blood in a lung cancer TIL therapy trial. Using T cell receptor sequencing on both functionally expanded T cells and neoantigen-loaded tetramer-sorted T cells, we identified tumor antigen-specific T cell receptors.

Dec 2, 2024 | techinasia.com | Timothy Chan

Kelvin Low co-authored this article. There’s a new subject for debate in the blockchain world: asset tokenization. More specifically, the conversation is around whether asset tokenization – the process of turning the ownership rights in physical things into tradable digital tokens – actually does what it promises. One camp believes it does. A joint report co-authored by Liquefy, Sidley, KPMG, and Colliers claims the usual benefits: lowering barriers to entry, efficiency, transparency, and so on.

Jan 5, 2024 | mondaq.com | James Morris |Timothy Chan |Etelka Bogardi |Wilson Ang

In this latest episode of our EMEA regulatory insights series colleagues from Australia, Hong Kong, and Singapore provide their thoughts and insights on what 2024 holds from a financial services regulatory perspective. Australia - 0:00 Hong Kong - 14:25 Singapore - 24:16 Spotify/ Apple The content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.

Dec 27, 2023 | regulationtomorrow.com | James Morris |Timothy Chan |Etelka Bogardi |Wilson Ang |James McGrath Morris |Simon Lovegrove

In this latest episode of our EMEA regulatory insights series colleagues from Australia, Hong Kong, and Singapore provide their thoughts and insights on what 2024 holds from a financial services regulatory perspective. The podcast can be found here.