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Dec 17, 2024 | 
ionanalytics.com | Jose Castro |José Roberto Castro |Avery Champion
Data Insight Geopolitical uncertainty in the fourth quarter cooled loan market issuance in the Americas, EMEA and Asia-Pacific (APAC) regions, but not enough to significantly impair 23% year-on-year (YoY) growth, according to Dealogic data. During a year when loan markets responded to interest-rate cuts in most major economies around the world, high volumes in 2024 have been based largely on refinancing existing leveraged debt.
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Dec 17, 2024 | 
ionanalytics.com | Claude Risner |Jose Castro |José Roberto Castro |Avery Champion
Data Insight This year has seen an impressive return to form for bond markets globally, as the Ukraine crisis and its after-effects hampered activity over the past two years. More than USD 8.75trn has flowed from investors into the coffers of issuers so far this year, according to Dealogic data. That is only narrowly down on the record years of 2021 and 2022, and up around 30% year-on-year (YoY).
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Nov 27, 2024 | 
nature.com | Jose Castro |José Castro
A new study reveals that metformin, a widely prescribed diabetes medication, can significantly improve health parameters in aged male cynomolgus monkeys — possibly by slowing the aging process. The findings represent an important step toward understanding how pharmaceutical interventions might, in the future, extend the healthspan and delay age-related diseases in humans.
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Oct 18, 2024 | 
nature.com | Kejun Ying |Jose Castro |José Castro |Alexander Tyshkovskiy |Sofiya Milman
AbstractWhile previous studies identified common genetic variants associated with longevity in centenarians, the role of the rare loss-of-function (LOF) mutation burden remains largely unexplored. Here, we investigated the burden of rare LOF mutations in Ashkenazi Jewish individuals from the Longevity Genes Project and LonGenity study cohorts using whole-exome sequencing data. We found that centenarians had a significantly lower burden (11-22%) of LOF mutations compared to controls.
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Sep 30, 2024 | 
ionanalytics.com | Jose Castro |José Roberto Castro |Avery Champion
Powered by Debtwire data, Loan Highlights reviews loan market activity across North America, EMEA, and APAC in 9M24. All data correct as of 27 September 2024. The loan market has responded to interest rate cuts in the main economies around the world and issuance in the Americas, EMEA and Asia-Pacific regions is on the way to having its best year since 2021, Dealogic data shows.
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Jun 27, 2024 | 
ionanalytics.com | Jose Castro |José Roberto Castro |Lucy Chapman
Data Insight Powered by Debtwire data, Loan Highlights reviews loan market activity across North America, EMEA, and APAC in 1H24. All data correct as of 26 June 2024. The loan market in the Americas, EMEA and Asia-Pacific regions is a useful gauge of improvement when compared with the previous year. To that end, combined volumes across the three regions amounted to USD 2.6trn in 1H24, marking a 13% rise from 2023 year to date (YTD).
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Mar 28, 2024 | 
ionanalytics.com | Jose Castro |José Roberto Castro |Carlos Martinez
Data Insights Last year’s loan issuance in the Americas, EMEA and Asia-Pacific was poor, standing 9.3% below the 2018-23 average, but there are few signs of a revival thus far in 2024. Combined issuance in the three regions reached USD 1.08trn in 1Q24 year to date (YTD), close to 1Q23’s USD 1.17trn, yet this remains less than the first-quarter results in every year since 2018.
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Nov 16, 2023 | 
ionanalytics.com | Mimi Lee |Jose Castro |José Roberto Castro
Data Insight The high interest-rate environment, combined with hopes that the hiking cycle is coming to an end, is driving companies to shorter tenors in the European leveraged loan market. The rolling quarterly average shows leveraged loan tenors have decreased over the past 12 months. While quarterly figures in 2021 and 2022 saw most loan tenors average between 6 and 6.5 years, these have dipped to 5.2 years in the 12 months ending in September.
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Sep 29, 2023 | 
community.ionanalytics.com | Jose Castro |José Roberto Castro
Pure Gym, a UK-based fitness club, has become the second company in a week to test demand for sterling-denominated senior secured notes (SSNs) in the European high-yield (HY) market. The firm previously announced a minimum GBP 300m sterling-denominated note on its dual-tranche deal, but ended up hiking this to GBP 475m (EUR 546.6m-equiv), pricing at 10% (versus 8.25% for the euro-denominated slice).
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Aug 29, 2023 | 
community.ionanalytics.com | Ben Watson |Jose Castro |José Roberto Castro
August is a good month to reflect on issuance over the course of the past year, ahead of the September push through to the holiday season and advent of the new year. While syndicated leveraged loan and high-yield (HY) bond markets have endured a challenging time during the past eight months, sentiment is far from rock-bottom thanks to softening expectations of a US recession, leveraged yields stabilising, and defaults merely trickling upward.
