Sofiya Milman

Oct 18, 2024 | nature.com | Kejun Ying |Jose Castro |José Castro |Alexander Tyshkovskiy |Sofiya Milman

AbstractWhile previous studies identified common genetic variants associated with longevity in centenarians, the role of the rare loss-of-function (LOF) mutation burden remains largely unexplored. Here, we investigated the burden of rare LOF mutations in Ashkenazi Jewish individuals from the Longevity Genes Project and LonGenity study cohorts using whole-exome sequencing data. We found that centenarians had a significantly lower burden (11-22%) of LOF mutations compared to controls.

May 21, 2024 | medrxiv.org | Amanat Ali |Sofiya Milman |Erica Weiss |Tina Gao

The authors have declared no competing interest. This work was supported by R01AG061155 (SM), U19AG056278 (ZDZ), P01AG017242 (ZDZ), and P01AG047200 (ZDZ). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Dec 6, 2023 | nature.com | Hamilton OH |Jarod Rutledge |Yun Ju Sung |Dan Western |Menghan Liu |Pat Kohlfeld | +9 more

AbstractAnimal studies show aging varies between individuals as well as between organs within an individual1,2,3,4, but whether this is true in humans and its effect on age-related diseases is unknown. We utilized levels of human blood plasma proteins originating from specific organs to measure organ-specific aging differences in living individuals.

Sep 1, 2023 | perspectivesinmedicine.cshlp.org | Sofiya Milman |Nir Barzilai |Albert Einstein College

Institute for Aging Research, Department of Medicine, Divisions of Endocrinology and Geriatrics, Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA Correspondence: Sofiya.milman{at}einsteinmed.edu

May 3, 2023 | perspectivesinmedicine.cshlp.org | Sofiya Milman |Nir Barzilai |Albert Einstein College

Institute for Aging Research, Department of Medicine, Divisions of Endocrinology and Geriatrics, Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA Correspondence: Sofiya.milman{at}einsteinmed.edu RATIONALE FOR STUDYING HUMAN EXCEPTIONAL LONGEVITY The U.S. Centers for Disease Control and Prevention (CDC) publishes an annual report on the rate of death from individual diseases, stratified by age groups (CDC 2023).