Jose Condori

Oct 6, 2023 | science.org | Guan-Hua Su |Susan Athey |Koon-Kiu Yan |Jose Condori

Research ArticleGENETICSINTRODUCTIONLentiviral vectors (LVs) are widely being used to deliver genes into hematopoietic stem cells (HSCs) or immune cells for therapeutic intent (1). Examples include gene therapy approaches for monogenic diseases such as immunodeficiencies and sickle cell disease (2–4) as well as the adoptive immunotherapy with T cells expressing chimeric antigen receptors (CARs) (5, 6).