Joseph A Cardina

Oct 17, 2024 | biorxiv.org | Rachel L. Dannenberg |Helen Wieffering Washington |Shijun Gao |Joseph A Cardina

AbstractDuring replication, lagging strand lesions are initially encountered by high fidelity DNA polymerase (pol) holoenzymes comprised of pol δ and the PCNA sliding clamp. To proceed unhindered, pol δ holoenzymes must bypass lesions without stalling. This entails dNMP incorporation opposite the lesion (insertion) and the 5' template nucleotide (extension).