Joseph Palmer

Apr 13, 2024 | onlinelibrary.wiley.com | Joseph Palmer |Nilesh Kumar |Luye An |Andrew White

Single-cell transcriptomics has revolutionized our ability to interrogate the dynamic nature of tissues. Here we provide a high-resolution map of the melanocyte stem cell population during quiescence. This map provides one of few examples highlighting broad heterogeneity in stem cells during the quiescent cell state. The map also unifies previous observations using other cell, molecular, and functional analyses to define the unique features of the quiescent melanocyte stem cell population.

Dec 20, 2023 | biorxiv.org | Joseph Palmer |Nilesh Kumar |Luye An |Andrew White

AbstractMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution.