Joseph Park

Nov 13, 2024 | jamanetwork.com | Joseph Park |Michael Levin |David Zhang |Nosheen Reza

Bidirectional Risk Modulator and Modifier Variant of Dilated and Hypertrophic Cardiomyopathy in BAG3 Key PointsQuestion  What is the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM)?

Nov 8, 2024 | biorxiv.org | Joseph Park |Thomas J. Wandless

AbstractExposure to exogenous and endogenous stress is associated with the intracellular accumulation of aberrant unfolded and misfolded proteins. In eukaryotic cells, protein homeostasis within membrane-bound organelles is regulated by specialized signaling pathways, with the unfolded protein response in the endoplasmic reticulum serving as a foundational example. Yet, it is unclear if a similar surveillance mechanism exists in the nucleus.