Josephine Solowiej-Wedderburn

3 weeks ago | biorxiv.org | John Davis |Josephine Solowiej-Wedderburn |Sebastian Vega |Jason A Burdick

AbstractFor tissue development, cells must generate contractile forces which are transmitted to their surrounding matrix or neighbouring cells via adhesion complexes. It is often envisaged that a simple linear counterbalance of cell generated stress with extracellular matrix (ECM) traction forces exists. However, experimental evidence indicates that modulating cell-ECM attachment does not necessarily lead to expected reciprocal changes in intercellular stresses.