Jason A Burdick

Oct 15, 2024 | nature.com | Jason A Burdick

AbstractAdditive manufacturing is an engineering tool that enables the creation of complex structures for biomedical use, such as 3D scaffolds for tissue engineering and regenerative medicine, as well as in vitro disease models for drug testing. In particular, lithography-based techniques such as digital light processing and volumetric additive manufacturing have enabled advances in the 3D processing of photoreactive resins into structured hydrogels.

Oct 1, 2024 | nature.com | Ashton C. Berger |Massimo Cristofanilli |Jason A Burdick |Virginia F. Borges

AbstractCollagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prognostication and develop more effective therapeutic strategies. In this study, using a combination of in vitro, in vivo and bioinformatic experiments, we show that type III collagen (Col3) plays a tumor-restrictive role in human breast cancer.

Sep 12, 2024 | nature.com | Jason A Burdick |Ankur Singh

AbstractPerfusable hydrogels have garnered substantial attention in recent years for the fabrication of microphysiological systems. However, current methodologies to fabricate microchannels in hydrogel platforms involve sophisticated equipment and techniques, which hinder progress of the field. In this protocol, we present a cost-effective, simple, versatile and ultrafast method to create perfusable microchannels of complex shapes in photopolymerizable hydrogels.