Joshua Hyman

Jun 11, 2024 | biorxiv.org | Varun Arvind |Joshua Hyman |Alice Huang |Peter Timothy Shyu

AbstractNeuromuscular contractures (NC) are a prevalent cause of joint deformity in children suffering from neuromuscular disorders or nerve damage, leading to persistent disability. The role of tendon in the development of NC remains poorly understood, with current treatments predominantly targeting muscle. Here, we establish a surgical model of NC in the hindlimb that recapitulates functional deformity and transcriptomic changes observed in human disease.