Varun Arvind

1 month ago | science.org | Varun Arvind |Emanuel J. Novais |Jonathan Oesterle |Daniel Maurer |Mya Vu |Haley Dugan | +5 more

AbstractMonoclonal antibodies (mAbs) targeting the influenza hemagglutinin (HA) can be used as prophylactics or templates for next-generation vaccines. Here, we isolated broad, subtype-neutralizing mAbs from human B cells recognizing the H1 or H3 HA “head” and a mAb engaging the conserved stem. The H1 mAbs bind the lateral patch epitope on HAs from 1933 to 2021 and a prepandemic swine H1N1 virus. We improved neutralization potency using directed evolution toward a contemporary H1 HA.

1 month ago | science.org | Varun Arvind |Emanuel J. Novais |Jonathan Oesterle |Jie Tu |Hangren Li |Xudong Liu | +18 more

AbstractDouble-perovskite films have been extensively studied in multifunctional fields due to their modifiability. Here, a controlled process strategy to induce chemical strain and anomalous Poisson deformation is proposed for perovskite-based films. The chemical negative strain in the local-ordering BiSmFe2O6 double-perovskite films can be regulated by oxygen engineering to cause the effectively tunable bandgap.

Jun 11, 2024 | biorxiv.org | Varun Arvind |Joshua Hyman |Alice Huang |Peter Timothy Shyu

AbstractNeuromuscular contractures (NC) are a prevalent cause of joint deformity in children suffering from neuromuscular disorders or nerve damage, leading to persistent disability. The role of tendon in the development of NC remains poorly understood, with current treatments predominantly targeting muscle. Here, we establish a surgical model of NC in the hindlimb that recapitulates functional deformity and transcriptomic changes observed in human disease.