Joydeep Baral

1 month ago | biorxiv.org | Joydeep Baral |Ching-Seng Ang |Paul McMillan |Kalyan Shobhana

AbstractNon-homologous end joining (NHEJ) is the sole pathway for repairing double-strand breaks (DSBs) in Mycobacterium tuberculosis during dormancy, relying on mycobacterial Ku (mKu) and ligase D, with mKu as the rate-limiting factor. Despite its essential role, the lack of structural information on prokaryotic Ku has hindered understanding of the molecular mechanisms underlying bacterial two-component NHEJ machinery.