Judy R Rees

Apr 1, 2024 | journals.plos.org | Daniel Walsh |Judy R Rees |Surabhi Mehra |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article Citation: Walsh DJ, Rees JR, Mehra S, Bourkas MEC, Kaczmarczyk L, Stuart E, et al. (2024) Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease. PLoS Pathog 20(4): e1012087. https://doi.org/10.1371/journal.ppat.1012087Editor: Suzette A.

Sep 29, 2023 | biorxiv.org | Daniel Walsh |Judy R Rees |Surabhi Mehra |Matthew E.C. Bourkas

AbstractPrion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious. Wild-type prions are responsible for the sporadic and infectious versions, while mutant prions cause inherited variants like fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD). Although some drugs can prolong prion incubation times up to four-fold in rodent models of infectious prion diseases, no effective treatments for FFI and fCJD have been found.