Juhyuk Park

Oct 21, 2024 | onlinelibrary.wiley.com | Hyun Kim |Juhyuk Park |Joon Pyo Kim |Jaeyong Jeong

1 Introduction Efficiently solving combinatorial optimization problems (COPs) is crucial, given their extensive applications in critical domains such as artificial intelligence, finance, drug discovery, cryptography, telecommunications, and more.[1] These problems, classified as nondeterministic polynomial-time hard (NP-hard), present significant computational challenges, with the difficulty of finding optimal solutions increasing exponentially with problem size.[2] The Ising model,...

Jun 13, 2024 | science.org | Juhyuk Park |Yang Liu |Michelle S. Keller

Editor’s summaryDNA-encoded chemical libraries enable screening of an enormous number of prospective drug compounds in parallel. The idea is that the functional components of each prospective drug are encoded with a DNA sequence that can be amplified later to identify the structure of a hit. However, incomplete syntheses can introduce errors in matching the tag to the functionality. Keller et al. devised a dual linker technique to ensure fidelity.

Jun 13, 2024 | science.org | Juhyuk Park |Yang Liu |Da Wu

Editor’s summaryWater transport can drastically change under different conditions and can even achieve superlubricity, meaning that friction virtually vanishes. The microscopic origin of this counterintuitive property is unclear. Using a cryogenic atomic force microscopy technique, Wu et al. directly imaged bilayer hexagonal two-dimensional water islands on homopolar graphene and heteropolar hexagonal boron nitride monolayers and measured their friction forces as a function of island area.

Jun 13, 2024 | science.org | Juhyuk Park |Yang Liu |Jiawei Zhao

AbstractMost insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo–electron microscopy (cryo-EM) structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos Aedes aegypti or Anopheles gambiae.

Jun 13, 2024 | science.org | Juhyuk Park |Yang Liu |Luuk Loeff

AbstractSeventh pandemic Vibrio cholerae strains contain two pathogenicity islands that encode the DNA defense modules DdmABC and DdmDE. Here we use cryogenic electron microscopy to reveal the mechanistic basis for plasmid defense by DdmDE. A structure of the DdmD helicase-nuclease reveals it adopts an auto-inhibited dimeric architecture. The prokaryotic Argonaute protein DdmE uses a DNA guide to target plasmid DNA.